(P400) A Dietary Pattern Representing the Metabolic Potential of Diabetes Pathogenic Ceramides

While there are established dietary recommendations for lowering other harmful metabolic lipids, such as cholesterol and triglycerides, there are currently no evidence-based dietary guidelines for reducing pathogenic ceramide levels. Ceramides are lipotoxic lipids that accumulate in obesity. Specific pathogenic ceramides, especially C16 and C18 ceramides, have been strongly associated with T2D and its related complications and comorbidities, as well as other obesity-related metabolic diseases. This poster discusses a study that identifies novel dietary approaches for lowering pathogenic ceramides and provides proof of principle for future ceramide diet research aiming to establish dietary guidelines for ceramide metabolism and diabetes prevention. Poster Authors: Sara Salas, MS, RD, Department of Nutrition and Integrative Physiology, University of Utah, Huntsman Cancer Institute, University of Utah; Hasan Basim Department of Nutrition and Integrative Physiology, University of Utah, Huntsman Cancer Institute, University of Utah; Rachel Hoobler, BS, RD, Department of Nutrition and Integrative Physiology, University of Utah, Huntsman Cancer Institute, University of Utah; Craig Busch, Department of Nutrition and Integrative Physiology, University of Utah, Huntsman Cancer Institute, University of Utah; Joshua Alvarez BS, Department of Nutrition and Integrative Physiology, University of Utah, Huntsman Cancer Institute, University of Utah; Jennifer Sinnott, Department of Statistics, The Ohio State University; Steven Moore, PhD, Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute; Anna Ibele, MD, Department of Surgery, School of Medicine, University of Utah; Monowarul Siddique, PhD, Department of Nutrition and Integrative Physiology, University of Utah; William Holland, PhD, Department of Nutrition and Integrative Physiology, University of Utah; Cornelia Ulrich, PhD, Huntsman Cancer Institute, University of Utah, Department of Population Health Sciences, School of Medicine, University of Utah; Scott Summers, PhD, Department of Nutrition and Integrative Physiology, University of Utah; and Mary Playdon, PhD, Department of Nutrition and Integrative Physiology, University of Utah, Huntsman Cancer Institute, University of Utah, Department of Population Health Sciences, School of Medicine, University of Utah. Funding Source: National Institutes of Health, Interdisciplinary Training Grant T32 Program in Computational Approaches to Diabetes and Metabolism Research, 5T32DK110966-01.